A new type of dementia has been identified. While it may look like Alzheimer’s disease, it differs in significant ways. Researchers suspect it’s even more prevalent than Alzheimer’s disease – and may be part of a mixed-dementia diagnosis – but that remains to be seen.

The new type of dementia is called limbic-predominant age-related TDP-43 encelopathy or LATE dementia. The symptoms of LATE dementia and Alzheimer’s disease can appear to be similar, but while Alzheimer’s disease is the accumulation of plaques (beta-amyloid proteins) and tangles (tau proteins) in the brain, LATE dementia occurs because of the misfolding of accumulated TDP-43 proteins in the brain.  Continue reading →